Fig 2: Knockdown of Src in NSCLC cells limited experimental metastases in vivo and inhibited Fn14-mediated NF-?B pathway. (A) H&E-stained lung sections and statistics of lung metastasis in BALB/c mice with tail vein injection of HCC827 cells with or without Src knockdown. (B) Representative images and quantitative analysis of the effect of Src knockdown on the expression of Fn14 and nuclear translocation of NF-?B p65 in vivo. *, p<0.05 versus the shSrc group. Scale bar, 200 µm. Arrows indicate metastatic tumors.

Fig 3: Immunofluorescence results. FITC-labeled secondary antibody appeared as green fluorescence following binding to p-p65. The nucleus appeared as blue fluorescence following DAPI staining (magnification, x200). A, control; B, IL-18 treatment; C, IL-18+QNZ treatment.

Fig 4: Inflammation and oxidative stress associated factors of sham and chronic OSA dogs(A) Representative bands of NLRP3, phospho-NF-?B-p65 and NF-?B-p65 as well as the ratio of NLRP3 to GAPDH and phospho-NF-?B-p65 to NF-?B-p65. (B) Representative band of CD68 and the ratio of CD68 to ß-actin. (C, D) Serum levels of TNF-a, SOD activity, XOD and MDA. *P < 0.05, *P < 0.01, ***P <0.001 vs. sham group, n=6 in each group.

Fig 5: NF-?B inhibitor reversed trophoblast cell proliferation, invasion, and migration induced by LPS. (a) I?Ba, p-I?Ba, and nucleus NF-?B p65 expressions in trophoblast cells. (b) Cell activity was determined by CCK-8 assay. (c, d) Cell migration and invasion were examined by Transwell assays. (e) Western blot was performed to determine MMP2, MMP9, snail, and E-cadherin levels in trophoblast cells. Scale bar = 100 µm. *P < 0.05 vs. control; #P < 0.05 vs. LPS.